Trulicity for weight loss without diabetes. 5 mg) compared to placebo in adults with type 2 diabetes with and without established cardiovascular disease. The active ingredient in Trulicity is dulaglutide, which belongs to a class of drugs called GLP-1 receptor agonists. In studies with or without other diabetes medications, weight loss in adults ranged from 12 lb (5mg) to 25 lb (15 mg). Both medications help lower blood sugar, reduce A1C, support weight loss, and decrease the risk of cardiovascular complications. They are also some of the most expensive prescription drugs on the market. 1 day ago · Does Trulicity cause hair loss? It is a question increasingly raised by patients using this once-weekly GLP-1 receptor agonist for type 2 diabetes management. Mounjaro is not a weight loss drug. Jan 5, 2026 · Certain GLP-1 and GIP/GLP-1 receptor agonists are specifically approved to help certain people with and without diabetes manage their body weight. It can cause weight loss as a side effect by reducing appetite and slowing digestion. Individual results may vary.